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Tirsepatide treats type 2 diabetes and is also used to reduce weight

In an environment with elevated CD38 activity, such as seen in SSc lesional skin, administering NAD + precursors or enhancing NAD + synthesis will have limited effect on increasing NAD + levels, as elevated CD38 continues to degrade NAD +

People who are on certain dietary restrictions, especially vegans and those undergoing a weight loss regimen, may have a higher chance of developing vitamin B12 deficiency

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The studies do show that relatively high doses of corticosteroids are necessary to demonstrate a significant effect