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doi: 10.1016/j.dmpk.2017.11.001 129 ManachCScalbertAMorandCRmsyCJimnezL

Other investigators have attempted to facilitate the availability of central brain-derived neurotrophic factor (BDNF) with injections of human BDNF directly into the patients brain with minimal positive results [17]

In addition to issues with absorption at the gut, it might also be noted that it takes ~8-12 weeks of consistent oral supplementation to achieve significant improvements in iron status, and even then, the improvement may be small (i.e., oral supplementation over this period may only get an anaemic athlete back to an iron deplete (non-anaemic) state)