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Collectively, these OFF-to-ON switching strategies illustrate therapeutic approaches in which GSH acts as a biological trigger for selective activation of cytotoxic agents in the GSH-rich tumor microenvironment

507 Therapeutic prospect in halting CS Given the significant impact of CS on disease pathology, there has been ongoing research into strategies aimed at quick diagnosis and therapy targeting of CS

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Carbonylation of the p46 and p54 isoforms of JNK kinase in human hepatic stellate cells activates activator protein 1 (AP-1), which stimulates the expression of procollagen type I, a fundamental step in liver fibrosis (83)

380,381 Hypercytokinemia induced by Th-17 was identified as an initial host response in severe cases of H1N1 infection in 2009