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Although CD8 + T cells sensitize target cancer cells to ferroptosis 225 , in syngeneic tumour models, it was found that ferroptosis-blocking antioxidant treatment improves responses to immunotherapy by preventing the immunosuppressive death of tumour-associated neutrophils 226

The manifestations of mitochondrial dysfunction are complex and diverse in SIC, mainly in the electron transport chain and oxidative phosphorylation abnormalities, mitochondrial structure abnormalities, oxidative and nitrite stress, mitochondrial calcium overload, mitochondrial autophagy dysregulation, and mitochondrial dynamics imbalance (3537)

10.1016/j.aca.2021.338578 141 HuangQ.-Y.ChenS.-R.ChenJ.-M.ShiQ.-Y.LinS

These can adversely affect neighboring cells that are as yet uninfected

Chamoun K, Benton CB, AlRawi A, Jacamo R, Williams P, Wang F, Zhang J, Daver NG, Garcia-Manero G, Kantarjian HM, Futreal A, Andreeff M