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The data generated during this phase help define the dose range that may be explored in subsequent studies and contribute to understanding exposure-response relationships, pharmacokinetic behavior and safety considerations associated with the investigational compound

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The electron transport chain (ETC), a crucial part of the OXPHOS, comprises four complexes: complex I (NADH dehydrogenase), complex II (succinate dehydrogenase), complex III (cytochrome c reductase), and complex IV (cytochrome c oxidase) (Tripathi and Ben-Shachar 2024)