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Importantly, UA has the ability to penetrate the blood-brain barrier (BBB) and has been recognized as a potent inducer of both autophagy and mitophagy in the central nervous system (223)

5 As humans migrated, early dogs may have followed, and by 11,000 years ago, at least five genetically diverse ancient dog breeds could be found in the human-settled regions of Northern Europe, Central and Southeast Asia, and the Americas

418,419 Although research on the pathophysiological mechanisms of DN covers multiple aspects, several pathways remain poorly understood, and the clinical application of treatment strategies remains limited

Determination of trimethylamine-N-oxide by a simple isocratic high-throughput liquid-chromatography tandem mass-spectrometry method

It is unknown whether tirzepatide causes thyroid C-cell tumors in humans