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Results The IDH1-R132H mutation in renal tubules exacerbated cisplatin-induced renal dysfunction To investigate the role of the IDH1-R132H mutation in renal injury, we used specific mutation of IDH1 in renal tubules ( Idh1 WT/Mut Ksp Cre ) in this study

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The activation of the nuclear E2-related factor 2 (Nrf2) receptor has arisen as a potential target for (poly)phenols in the recent literature (Reference Satta, Mahmoud and Wilkinson84)