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Simultaneously, silybin improves endothelial dysfunctiona critical link in the onset of inflammationby lowering asymmetric dimethylarginine (ADMA) levels, thereby reversing nitric oxide synthase inhibition and increasing the bioavailability of NO, which possesses anti-inflammatory and vasodilatory functions

RT-PCR reverse transcription-polymerase chain reaction the level of expression of a target polynucleotide or polypeptide is increased or reduced by at least 10%, 20%, 30%, 40%, 50%, or greater than 50% as compared to an appropriate control value

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Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice