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Nat Rev Drug Discov 21 , 578600 (2022)

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4.3 HIV co-infection and antiretroviral therapy HIV-positive individuals are at increased risk of parkinsonism due to basal ganglia vulnerability to viral neurotoxicity, chronic inflammation, and mitochondrial stress (Denaro et al., 2022

By occupying molecular sites and causing steric hindrance, these proteins can partially shield high-affinity immune recognition sites, thus limiting the accumulation of additional opsonins

Extended room temperature exposure of 24 hours or more means you should discard the vial