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10.1021/nn403772j 182 ZhangB.LiuQ.LiuM.ShiP.ZhuL.ZhangL.et al (2019)

Proc Natl Acad Sci USA 107:832837 Nakai R, Varnum S, Field RL, Shi H, Giwa R, Jia W, Krysa SJ, Cohen EF, Borcherding N, Saneto RP et al (2024) Mitochondria transfer-based therapies reduce the morbidity and mortality of Leigh syndrome

Two capsules daily (1200mg) aligns with therapeutic ranges used in some clinical protocols

The other pathway involves sterol o-acyltransferase 1(SOAT1) in human pancreatic ductal adenocarcinoma (PDAC) cells and NM-6 leukemia cells deficient in solute carrier family 47 member 1 (SLC47A1) to produce fatty acid cholesteryl esters and enhance iron apoptosis sensitivity [71]

1 ng/0.1 ml saline/each eye) is given at either 20 min after L-NAME or, lately, at 48 h after L-NAME, the regular retrobulbar L-NAME injection findings disappear