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Therefore, developing effective yet low-toxicity therapeutic agents for CRC may constitute a pivotal strategy to enhance overall treatment efficacy

The miR-4488 copy-number values were extracted from the standard curve according to the MIQE guidelines (Bustin et al, 2010)

An 8-week-old germ-free female C57BL/6J mice were housed in an isolator (CEP Standard Safety, McHenry, IL, USA) with open cages in the University of Alberta Axenic Mouse Research Unit