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More importantly, metformin treatment was shown to suppress senescence of mouse renal TECs under hyperglycemic condition (182)

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CrossRef Realworld clinical features, healthcare utilization, and economic burden in decompensated cirrhosis patients: A national database Hankil Lee, Beom Kyung Kim Journal of Gastroenterology and Hepatology .2022

What to Do If One Medication Isn't Working Well Enough If Mounjaro or Wegovy alone reaches a dose ceiling without satisfactory results, your doctor has several evidence-based options: continue escalating the single agent to its maximum recommended dose, switch to a different drug class (such as SGLT2 inhibitors or older lipase inhibitors), or consider a combination approved by clinical evidencesuch as metformin plus GLP-1 therapy for patients with prediabetes

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