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Microbial-derived metabolites, including but not limited to SCFAs, exert distal immunomodulatory effects through systemic circulation and vagus nerve signalingnotably regulating Treg cell differentiation and suppressing neutrophilic infiltration in bronchial tissues via G protein-coupled receptor (GPCR) signaling pathways ( 2 Methods 2.1 Search strategy To identify published studies, we conducted a comprehensive search of PubMed and Embase databases, covering records up to January 2025

Future rigorous clinical trials are required to clarify its efficacy specificity, address long-term safety concerns in the PD population, and evaluate its potential cost-effectiveness advantages