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In this report, we reveal a ferroptosis signature in MS patient samples, reflected by elevated levels of labile iron, peroxidized phospholipids, and lipid degradation products, such as 4-hydroxy-2-nonenal (4-HNE)

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When determining the Alanine to Lysine ratio as an indirect measure of mitochondrial distress we found that unaffected children had an average ratio of 5.8 and those with konzo have an average ratio of 6.9, both of which are substantially higher than the expected ratio of less than 3 for healthy adolescents (Fig

Gene expression analysis To obtain further insight into the mechanisms of BPC-157 participation in cell signal transduction, we carried out a quantitative real-time PCR using a Signal Transduction Path-wayFinder RT2 Profiler PCR Array, which contained a set of primers for 84 key genes representative of 18 different signal transduction pathways