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Animals Pregnant SpragueDawley (SD) rats (approximately 400 20 g per animal

Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices

10.1007/s11940-008-0043-8 39

Introduction Myocardial ischemic disease caused by coronary artery disease is one of the major causes of morbidity and mortality worldwide ( Ferroptosis is a type of iron-dependent cell death caused by a disturbance in the antioxidant system and lipid peroxidation, as well as elevated levels of reactive oxygen species, ultimately resulting in cell death ( The enzyme Spermidine/Spermine N1-Acetyltransferase 1, which is encoded by the Sat1 gene, is primarily localized in the cytoplasm