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Some drug, but probably not enough, got through For AOD9604, large molecule size wouldnt have reduced bioavailability to zero, and the use of polyethylene glycol as an excipient may have increased bioavailability slightly13, however there is the distinct possibility that not enough of the drug got through the gastrointestinal tract to make a therapeutic difference. In summation: Given the stark contrast between the biohackers and the institutional scientists, we have the selective release of fats from the fat cells in obese or lean individuals (depending on who you ask) to justify using AOD-9604 for biohacking weight loss

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Weight loss was primarily from fat mass rather than lean mass, and the treatment was generally well-tolerated with no significant adverse effects on glucose metabolism, insulin levels, or IGF-1 levels

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