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One example is vitamin D, which experienced a rapid surge and widespread hype in the 2000s, followed by a period of conflicting headlines and public skepticism, before a stronger evidence base emerged to establish its benefits and safety. NAD+ appears to be following a similar trajectory of early excitement, some overstated fears, and, now, a growing body of research helping provide more insight into its benefits

That framing creates confusion, unrealistic expectations, and disappointing outcomes

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[1] This is why IV and injectable glutathione are considered far more effective delivery methods

Accordingly, a shift toward more mechanism-informed classification models is needed