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For the difference between irritant and allergic reactions, see Its Complicated: Allergic Versus Irritant Reaction

Int J Mol Sci 22:7449

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(Occasionally, an acute rupture of the Achilles tendon will be treated with casting of the foot and ankle rather than surgery.) Whether a doctor recommends surgery, and what type of surgery he or she recommends, depends on the nature of the Achilles damage as well as the patient and his or her health, lifestyle, and preferences

The study was limited to people of European origin and may not apply to other populations, which may explain the reason why we did not find a causal association between SOD1 and ALS