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There are four main causes: 1) vascular factors, such as atherosclerosis (Stefanadis, 2013), hypertensive arteriosclerosis, and arteritis

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The conspicuous blood cortisol awakening response is the net daily increase in blood cortisol within 1 hour of awakening (282)

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On day 11, ethanol and pair-fed mice were gavaged early morning with a single dose of ethanol (5 g/kg b.w.) or isocaloric dextrin-maltose, respectively, and sacrificed 9 hours later 24

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Indeed, superoxide can undergo dismutation to H 2 O 2 , a mild oxidant that can be converted to the highly reactive hydroxyl radical in the presence of transition metals (Fe 2 + , Cu + ) by means of the Fenton reaction

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