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Diabetic peripheral neuropathy Diabetic neuropathy involves chronic hyperglycemia damaging small blood vessels that feed peripheral nerves (microangiopathy), along with metabolic disruption, oxidative stress, and advanced glycation end-products damaging nerve proteins

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Some side effects of direct factor Xa inhibitors may include: Dizziness Hemorrhage Abdominal Pain Pruritis Nausea (1)(12) Direct factor Xa inhibitors have several drug interactions and thus, the healthcare provider must review any potential interactions before initiating this medication