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Description

tabacum leaf tissues, and first-strand cDNA was synthesized using oligo-(dT) 15 primers

Blood 128(9):1174-80, 2016

Current clinically validated siRNA therapeutics, such as patisiran and givosiran, utilize optimized modification patterns combining 2-OMe, 2-F, and phosphorothioate backbone linkages to achieve sustained gene silencing lasting up to 680 days in hepatocytes, whereas unmodified siRNAs lose activity within days [58]