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A recent study by Jeon and colleagues showed that senescent chondrocytes accumulate around traumatic cartilage lesions and are associated with the development of arthritis

SAM is regenerated again and again in a permanent cycle: it releases its methyl group in various reactions, and then goes through a series of reaction steps, through which it receives a new methyl group and is thus available again as a methyl donor

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LC-MS/MS analysis The LC-MS analysis was performed using an Orbitrap Fusion tribrid mass spectrometer (Thermo Scientific) connected to an Ultimate 3,000 nano-UPLC system (Thermo Scientific)

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