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Although speculative, it could be hypothesised that this proposed increase in susceptibility of OPCs to ROS-induced damage compared to other brain cell types could, at least in part, be driven by ROS induced alterations in DNA methylation in these cells [6, 30, 32]

TAMs are characterized by elevated glutamine utilization, which is reflected by their high expression of both glutamine transporters and catabolic enzymes 43,44

16 These impaired DNA modifications can accelerate aging and cause neurodegenerative, carcinogenesis, autoimmune, cardiovascular, and other diseases

Moreover, prebiotics administration in PD patients helps in restoration of gut microbial diversity, which often reduced due to dysbiosis in GM (113)

Evaluation of the impact of hepatitis B vaccination among children born during 19922005 in China