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It occurs at the level of gene transcription [11, 12], epigenetic regulation [13,14,15], post-translational modifications of core and accessory cell death machinery components [16,17,18], organelle-specific mechanisms [19], and organelle crosstalk [20, 21]

bioRxiv2023 Jul 19

Additionally, ALS patient-derived induced astrocytes (iAstrocytes) were neurotoxic toward mouse motor neurons and their expression levels of disease-associated markers, including GFAP, CX43 and Ki-67, and miRNA profiles varied among patients, suggesting the astrocytes heterogeneity in ALS (Gomes et al., 2022)

All subjects were asked to return any remaining capsules on the day of the OPU to assess the adherence rate

Every secondary case requires careful assessment of existing scar tissue, cartilage availability, and structural integrity