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GLP-1 medications target the part of the brain that controls appetite, helping you feel satisfied with smaller portions and reducing constant food thoughts

Impaired SPM biosynthesis and signaling contribute to sustained plaque macrophage activation, defective efferocytosis, and expansion of the necrotic core, whereas restoration of SPM pathways enhances apoptotic cell clearance and promotes a pro-resolving macrophage phenotype (61, 62, 106, 131)

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The water-soluble nature of B12 means several things for patients : the vitamin requires regular dietary intake to maintain optimal levels, it can be lost during food preparation (particularly with prolonged cooking or boiling), and therapeutic doses are generally considered safe as excess is eliminated through the kidneys, though the body's substantial hepatic storage also plays a role in B12 metabolism