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Lancet Psychiatry 9:815827 Tate W, Walker M, Sweetman E, Helliwell A, Peppercorn K, Edgar C, Blair A, Chatterjee A (2022) Molecular mechanisms of neuroinflammation in ME/CFS and long covid to sustain disease and promote relapses

This hypothesis is supported by post-mortem evidence of reduced pyruvate dehydrogenase activity in the brains of individuals with ASD (Gu et al., 2013), which may impair the conversion of pyruvate to acetyl-CoA, leading to mitochondrial dysfunction and accumulation of lactate and alanine

The impaired Treg cell function, phenotypic alteration and disrupted Treg cell/Th17 cell balance have been suggested in the pathogenesis of psoriasis (Bovenschen et al., 2011

& Colbourne, J