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Cysteine, a constituent amino acid of glutathione, is critical for antioxidant defense

Metabolic heterogeneity further shapes responses: tumors with high cysteine dependency or elevated baseline ROS may favor ferroptosis upon PD-L1 blockade

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In the intestine, GRP becomes available to the gut microbiota, which can metabolize it to SFN, SFN-nitrile, glucoerucin, erucin, or erucin-nitrile (Figures 1, 2)

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