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2022 [cited 2024 Feb 26];14:1287

Targeted metabolomics was employed to measure intracellular glutamine levels in PIK3CA -MT HCT116 cells following aspirin treatment and hypoxic stimulation

Therapies and Models of Citrin Deficiency While the dysfunction of citrin manifests in a complex clinical phenotype across different life stages, therapeutic options remain limited, and no current treatment addresses the underlying metabolic dysregulation comprehensively

On the other hand, studies report that MK-677 has a considerably longer half-life of 4-6 hours, and daily oral intake can significantly increase GH and IGF-1 levels [5, 7]