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doi: 10.1016/j.phrs.2020.104919 51 RaisonC

Steps prior to initiating immunotherapy Because patients with cancer can present with toxicity as a result of previous therapies, baseline physical examination, laboratory tests, and imaging can be used as a reference for any newly observed AE that occurs during immunotherapy

Moreover, it emphasizes the central role of mitochondrial dysfunction and oxidative stress in multiple organ failure

the volumes used here are well within this limit [19]

However, there are three main obstacles to the effective clinical use of nanoparticle formulations: long-term safety assessment clinical validation and production method standardization