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In LFs, GLS1i blocked TGF-induced cellular pro-collagen and -SMA with a EC 50 of 70 7 and 53 8 nM, respectively

In addition, we also observed lower expression of BAX and caspase 3 and higher expression of Bcl-2 in hyperplastic prostate tissues compared with normal prostate tissues, which showed that with the down-regulation of GPX3, the apoptosis level of hyperplastic prostate was inhibited at the tissue level

The tumor cell line, SH-SY5Y, is noteworthy because in the dead cells phase it is the second group with the highest percentage representation within the four cellular processes analyzed (live cells, early apoptosis, late apoptosis and dead cells), from 11 to 15%

In two 2006 studies, another gene that has implications for the disease, called HTRA1 (encoding a secreted serine protease), was identified

The sequence read archive