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In contrast, it significantly improves anti-PD-1 responses in PD-1 refractory microsatellite stable CRC

Mohamed HI, Ullah I, Toor MD et al (2025) Heavy metals toxicity in plants: understanding mechanisms and developing coping strategies for remediation: a review

Specifically, free ferric iron is shuttled into cells bound by transferrin (TF), and reduced to ferrous iron via catalyzing by endosomal six-transmembrane epithelial antigen of prostate 3 (STEAP3), subsequently ferrous iron is released into the cytoplasm through divalent metal transporter 1 (DMT1) to expand the labile iron pool (LIP) (Xu et al., 2024)

Specifically, dysregulated neuronal energy metabolism can trigger apoptotic cascades via mitochondrial membrane potential collapse or abnormal pyruvate dehydrogenase complex phosphorylation, while targeting monocarboxylate transporter MCT2-mediated lactate shuttling or mitochondrial calcium uniporter (MCU) activity has emerged as a promising therapeutic strategy for neurodegenerative disorders

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