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Endoscopic remission at Week 52 15* ENTYVIO IV ENTYVIO SC Placebo CI=confidence interval

Absolute contraindications: Known allergy to either peptide or its components Active cancer (insufficient safety data) Pregnancy or breastfeeding (insufficient safety data) Severe immunocompromise (theoretical concern) Relative contraindications (require careful consideration): History of cancer (consult a medical advisor) Major cardiac disease (monitor closely) Severe liver or kidney disease (may affect clearance) Active infections (wait until resolved) Bleeding disorders (monitor injection sites carefully) Special populations: Elderly subjects: usually well tolerated, no dose adjustment needed Subjects with multiple conditions: enhanced monitoring recommended Those on multiple medications: review for possible interactions Drug Interactions The peptides have minimal documented drug interactions

Since GSTO1 knockdown has been known to result in increased protein glutathionylation 14 , glutathione depletion by CHAC1 could possibly contribute in restoring the glutathionylation balance

Ti y, GSH tham gia vo Giai on II ca qu trnh thi c gan - phn ng lin hp (conjugation)

Tian, H.Y