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Occurrence mechanism of ferroptosis Ferroptosis is a result of cellular metabolism and an imbalance in redox homeostasis (Fig

Sachan and Rhew, 1983

Specifically, it represents a modified version of amino acids 176-191 from the growth hormone molecule, the segment researchers identified as responsible for growth hormones lipolytic (fat-breaking) effects

ATF4 associates with amino acid response elements (AARE) and promotes the transcription of genes related to amino acid metabolism and stress response, in particular SLC7A11, thereby enabling cells to cope with amino acid-limited conditions (Koppula et al., 2021b)