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Spiro-Containing Derivatives Show Antiparasitic Activity against Trypanosoma Brucei through Inhibition of the Trypanothione Reducatase Enzyme

Immunogenicity (an unwanted immune reaction) is a stated risk in FDA materials on protein-based therapeutics

Further, patients had multiple symptoms and comorbidities, which adds to the complexity of evaluating the impacts of treatments on the disease as well as on specific symptoms