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the more stable and accurate BDNF measurements should be determined and find out which source of BDNF is the most reliable biomarker of MDD, as concentrations of BDNF markers in the circulation do not always reflect the CNS concentrations

Notably, integrin-dependent signaling is known to promote the stabilization of microtubules at the leading edge of migrating cells [45, 46, 50]

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This approach is more complex and, frankly, carries a higher burden of proof