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They produce metabolites, particularly short-chain fatty acids like butyrate, that regulate immune activity, maintain the integrity of the gut lining, and influence the immune behavior in tissues far from the gut itself

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Under these conditions, the increased secretion of counterregulatory hormones stimulates FFAs oxidation in the liver and accelerates the production of ketone bodies, which are metabolized in muscle, adipose tissue and, most importantly, in heart and brain ( As demonstrated in a recent meta-analysis, SGLT-2i treatment is associated with increased plasma fasting glucagon levels in patients with diabetes compared with non-SGLT-2i treatments with a reduction of insulin and increased ketone body levels ( via GH upregulation

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All the assessment tools and management methods for sleep disturbances are displayed in Table 3