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This increase was observed in both epithelial cells (PCK + PD-L1+) and stromal cells (DAPI + PD-L1 + PCK- in stromal compartment) (Supplementary Figure S7C)

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BBB breakdown can lead to neurotoxic accumulations of fibrin, thrombin, and plasmin, and red blood cell extravasation, the release of hemoglobin and ferrous iron, causing reactive oxygen species (ROS), which can all injure dopaminergic neurons [513]

Boutin S, Hildebrand D, Boulant S et al (2021) Host factors facilitating SARS-CoV-2 virus infection and replication in the lungs