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TABLE 2 Summary of preclinical studies on cannabinoid modulation in fibrosis

Smith KR, Borchardt RT

They imply predictable human outcomes from a substance that has no approved clinical indication

These results indicate that cagrilintides metabolic effects are receptor-dependent and that functional AMY1R/AMY3R signaling is essential for proper nutrient partitioning and energy balance regulation

However, other data show that Bs can decrease A accumulation and reduce cognitive deficits in mice models 67 and slow cognitive decline in people with Alzheimer's disease