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[DOI] [PMC free article] [PubMed] [Google Scholar] [77].Li MO, Flavell RA

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18 For example, in one study, researchers discovered that when GSH is depleted in the hippocampus regions of an elderly person the healthy brain suffers mild cognitive impairment, which is known to be present in the earlier stages of AD

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However, these results were in human PBMCs, and given that NQO1 protein content increased in response to stimulation in the current investigation, the gene expression may occur earlier in skeletal muscle than in PBMCs