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Dose-dependent organ toxicity, long-term safety profiles, and potential interactions with medications commonly administered to AKI patients, such as antibiotics, vasopressors, and nephrotoxic agents, must be systematically evaluated

Since we demonstrated in a previous study that mitochondria in Wobbler motor neurons have abnormal morphology (Stein et al., 2021) and mitochondrial malfunction is known to be present in Wobbler animals (Xu et al., 2001