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& Hayward, A

Belcher J

doi: 10.1164/rccm.201512-2380OC 56 SunYByonCHYuanKChenJMaoXHeathJMet al

the ratio of cells to particles ranges from 1 : 100 to 100: 1 and any integer values in-between and in further embodiments the ratio comprises 1 :9 to 9: 1 and any integer values in between, can also be used to stimulate T cells

Increased expression of CREM in CD4 + T-cells has been linked with effector cytokine expression in psoriasis, PsA (83) and other autoimmune diseases, including SLE (84) and juvenile idiopathic arthritis (85)