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Patients with evidence of vitamin B 12 deficiency and chronic gastrointestinal symptoms such as dyspepsia, recurrent peptic ulcer disease, or diarrhea may warrant evaluation for such entities as Whipple's disease (a rare bacterial infection that impairs absorption), Zollinger-Ellison syndrome (gastrinoma causing peptic ulcer and diarrhea), or Crohn's disease

On the other hand, talin knockdown promotes negative durotaxis of MDA-MB-231 cells by suppressing adhesion reinforcement, which is observed on ~ 20 kPa substrates [96]