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Within its 539 amino acids, two independent activation domains have been identified: activation function 1 (AF-1) (located between residues 103 and 372) that is essential for transcriptional activity of full-length androgen receptor, and activation function 5 (AF-5) (located between residues 362-486) that is required for transactivity of a constitutively active androgen receptor, which lacks its LBD (103)

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Goulis, Pantelis Zebekakis, Kalliopi Kotsa Journal of Personalized Medicine.2022

3.2 Hydrogels for cell and mitochondria protection In the context of OA, both apoptosis and autophagy imbalances play critical roles in disease progression (Su et al., 2019)

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