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Key Points Aberrant c-MET pathway activation occurs frequently in gastrointestinal tumours and can result from multiple mechanisms, including c-MET protein overexpression, MET amplification or enhanced transcription and/or aberrant autocrine or paracrine secretion of HGF Activated c-MET signalling results in enhanced cancer cell proliferation, survival and invasion

There was a dose-finding trial done by Eussen et al

The science behind the product: The function of glutamine in stimulating glycogen synthase, the enzyme that controls the synthesis and storage of glycogen fuel in muscles and liver, may provide a mechanism by which glutamine supplements promote enhanced fuel stores

In healthy adults, plasma concentrations of urolithin A-glucuronide reach a peak of approximately 110 ng/mL and 30 ng/mL at 24 h post consumption of pomegranate juice (107 mg of ellagitannins and ellagic acid) (28) and frozen red raspberry beverage (29 mg of ellagitannins and ellagic acid) (29), respectively

They achieve this by partially disrupting the balance of certain chemicals in cells to eliminate tumor cells and reverse resistance