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British American Tobacco is the best partner for Reynolds Americans next phase of growth, and together the two companies will create the leading portfolio of tobacco and next-generation products for adult tobacco consumers. Nicandro Durante, British American Tobaccos chief executive officer, added: We are very pleased to have reached agreement with the board of Reynolds American as we believe that the combination of our two great companies has a very compelling strategic and financial logic and will provide a lasting benefit to shareholders, employees and all other stakeholders

4 Unique vulnerabilities of teens and young adults 4.1 The developing adolescent brain and cardiovascular system Adolescence is a critical neurodevelopmental period characterized by significant remodeling of brain circuits, particularly those involving the prefrontal cortex and limbic system, which govern executive function, reward processing, and emotional regulation