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Sarkar S, et al

Furthermore, naringenin, a promising bioactive compound, is postulated to modulate cellular adaptive responses to hypoxic conditions through its influence on HIF-1, TNF, and NF-B signaling cascades, along with estrogen-mimetic activities

GSSG/GSH ratio provides oxidative stress context

The high unsaturated fatty acid content in the brain, the formation of free radical by-products as a result of high oxygen use, high lipid peroxidation and weak antioxidant defense system, the high reducing potential of various neurotransmitters, and the presence of redox-catalytic metals such as iron and copper can be counted among the reasons why the brain is more sensitive to oxidation