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6bd), with IC50 values indicating enhanced cisplatin resistance (Table S8)

Sulfasalazine has also been used for prolonged periods to maintain remissions

Age-related chromatin compaction slows and blunts these responses, contributing to impaired cell-mediated immunity

doi: 10.1038/s41598-020-67729-5 23 Lara-ReynaSScamblerTHolbrookJWongCJarosz-GriffithsHHMartinonFet al

Potential limitations include: Limited long-term human data Variable patient response Cost considerations Need for ongoing monitoring Off-label prescribing considerations These therapies are generally avoided in patients with: Active malignancy Pregnancy or breastfeeding Significant uncontrolled endocrine disease Certain metabolic conditions Monitoring and Safety Where prescribed, monitoring may include: IGF-1 levels Functional recovery Sleep quality Rehabilitation tolerance Adverse effects Overall clinical progress Treatment should always be part of a broader recovery plan rather than a standalone intervention