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11,13,16 In our recently published pre-clinical study, we showed that treatment of very early orthotopic pancreatic cancer with HGF-c-MET inhibitors plus the chemotherapeutic agent gemcitabine (G) inhibited disease progression

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(172) demonstrated in diabetic rat models that TMAO treatment exacerbated renal inflammation and fibrosis through activation of the NLRP3 inflammasome, promoting IL-1 and IL-18 release and increasing pro-fibrotic TGF-1 expression