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have observed that HIF is highly active under hypoxic conditions and promotes the transcription of the target gene ITGA6 , which, in conjunction with other integrins, is enriched in breast stem cells and promotes the acquisition of MDR phenotypes in breast cancer 48

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What might be the reason for this initial decline in well-being

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Kelch-like ECH-associated protein 1 (KEAP1), an E3 ubiquitin ligase, controls NRF2 activity post-translationally