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Therefore, the development of long-acting VIP analogs with strong bronchodilatory effects [76,82] or modulators of the VIP-VPAC2 signaling pathway may provide clinically useful agents for the treatment of asthma [92]

In contrast, many studies on metabolic modulators, herbal formulations, or supplements have been constrained by small sample sizes, short durations, and reliance on surrogate endpoints such as NT-proBNP reduction or improvements in left ventricular ejection fraction

In order to maintain an appropriate supply of glutamine, an essential substance for survival of cells and proliferation, a recent study also discovered that proline production declines in the absence of glutamine [26]

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